Review Of The Study Of HIV And Transplants - 747 Words

In this study we evaluated 12 HIV+ patients that received kidney transplantation at Montefiore Medical Center from 2010-2015. The objective of this study was to recognize the population of complement binding donor specific antibodies using C1q methodology (One Lambda). Our target cohort group where special cases that may be not fully understood by the clinical team due to HIV+ status. C1q testing may provide better understanding of complement binding activity post-transplantation and clinicians will be able to deliver greater quality medical care. All patients had a negative CDC crossmatch upon transplantation. Out of 12 patients, 6 had positive Flow crossmatch upon transplantation. All patients where routinely tested for antibody†¦show more content†¦Patients with new developed antibodies are at a higher risk for developing acute or chronic antibody mediated rejection (AMR) (1). Many HIV+ patients develop HIV nephropathy and require kidney transplantation (2). HIV binds to the surface proteins that bind antigens on host cells. HIV protein gp120 binds a combination of CD4 and CXCR4 on T-cells. Cells are killed by direct cytopathic effect, which is an anti-viral response or by transformation of host cells via oncogene expression (3). HIV effects immune system and may interfere with interpreting correct results or placing compatible organs (2). Crossmatching an HIV+ patient with potential donors poses serious challenges due to HIV induced B- cell deregulation and presence of auto-antibodies. HIV+ patients may have false positive test results that may be difficult to interpret or find compatible organs. HIV+ cases can create confusion, therefore supplementary testing is needed to better assess suitability of the organ or graft tolerance (2, 3). New tests have been developed that target a different route of antibody activity. This is a great opportunity to disc over how C1q testing may benefit those special cases of HIV+ patients (4). Antibody screening tests have been in use for a long time and surgeonShow MoreRelatedAnimal Testing Must Be Banned Essay1014 Words   |  5 PagesHealth Organization out of 200,000 released mediations only 240 are labeled as essential (1). Corneal transplants were delayed for 90 years and blood transfusion were delayed 200 years due to animal studies (1). Less then two percent of human illnesses of 1.16% are ever seen in animals (1). Scientists believe that by performing these tests on animals is to ensure the safety of the new drugs (HIV drugs, vaccines and animal testing 2). Also to see whether such products might be effective in humansRead MoreProfessional Practice And How Does It Differ Between Patient Facing Versus Laboratory Based Clinical Scientists?1981 Words   |  8 Pagesto embody each of these to be an effective healthcare scientist. 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